PSUN47 Increased Prevalence of Metabolic Syndrome Among Adult Filipinos with Hypothyroidism

Abstract Dyslipidemia in patients with hypothyroidism results from effects of thyroid hormones on lipid metabolism. Hypothyroidism is characterized by a state attenuated basal plasma insulin, high insulin resistance and hypothyroidism-induced hemodynamic alterations. All which are risk factors for the development metabolic cardiovascular diseases. In this study, we determined prevalence syndrome among adult Filipinos compared clinical laboratory characteristics those versus without syndrome. We also validated body mass index as surrogate marker waist circumference diagnosis conducted prospective study 120 Filipino adults hypothyroidism. Anthropometric blood pressure measurements were performed followed extraction fasting glucose, profile, stimulating hormone, free thyroxine levels, triiodothyronine levels anti-thyroid peroxidase antibody levels. The presence was using WHO criteria race-specific cut-offs circumference. Both between Significant differences two-way ANOVA while heterogeneity categorical variables chi-square or Fisher exact test. Use BMI estimated Pearson's correlation coefficient kappa statistic. data analyses Stata version 17.1 level significance at p<0.05. overall 40.00% (95%CI: 31.17%–49.34%). male to female ratio 1: 2 (41: 79 patients) primary comprised 88.89% (n = 109) cohort. Patients have significantly higher mean (females: 89.73 ± 7.50 cm vs. 80.13 10.13 cm; males: 93.16 10.25 83.52 8.25; p<0.001), proportion diabetes (22.92% 1.39%; p<0.001) hypertension (45.83% 8.33%; without. Furthermore, median 11.59 (13.41) pmol/L; p=0.043). Waist highly directly correlated (r2=0.7471) but showed only weak agreement (K=0.4970). use place had diagnostic accuracy 93.80% (6 missed index). There no significant terms age, sex, etiology hypothyroidism, hormone triiodothyronine, autoantibody Our that increased 40% general euthyroid population. most important drivers identified circumference, index, mellitus. Presentation: Sunday, June 12, 2022 12:30 p.m. - 2:30